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Last Updated: Feb 14, 2014 URL: http://libguides.lhl.uab.edu/sysrev Print Guide Email Alerts

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Introduction

In today's research environment, everyone seems to be doing a review of some type.  Because so many different groups (faculty, students, researchers, etc.) are doing "a review" the term, review, gets used pretty loosely especially if there is not an adjective in front of the word identifying what kind of review is being done.  Most reviews fall into the following types: literature review, narrative review, integrative review, evidenced based review, meta-analysis and systematic review. This LibGuide will provide you a general overview of the specific review, offer starting points, and outline the reporting process.  Naturally, if you need more in-depth information, please contact one of the reference librarians

Please let us know if this LibGuide is useful to you, additional information that you would like us to add, or any suggestions for improving this LHL Guide.  Use the FEEDBACK box on this page to send us your comments or suggestions.  Thank you for using LHL Guides.

 

Hierarchy or Levels of Evidence Pyramid

Not all evidence is equal.  Presented below are three pyramids that show the different levels of evidence sources and explanations of each level.  Of course, the best are at the top and as the pyramids indicate, you have much fewer resources at the top than at the bottom of the pyramids.


(See the Database Information page for more information about the Trip Database.) 

 

Hierarchy of Evidence

Not all evidence is judged to be of equal value; that is, there are hierarchies of research design that are evaluated to have different strengths or different levels of value in the decision making process.  See the two charts below -- one graphically represented, one textually to help understand the concepts important to critical appraisal, assessment, and evaluation of research.

The Evidence Pyramid

(Source: SUNY Downstate Medical Center. Medical Research Library of Brooklyn. Evidence Based Medicine Course. A Guide to Research Methods: The Evidence Pyramid.)

 

Levels of Evidence

Category I Evidence from at least one properly randomized controlled trial.
Category II-1 Evidence from well-designed controlled trials without randomization.
Category II-2 Evidence from well-designed cohort or case-control analytic studies preferably from more than one center or research group.
Category II-3 Evidence from multiple times series with or without intervention or dramatic results in uncontrolled experiments such as the results of the introduction of penicillin treatment in the 1940s.
Category III Opinions of respected authorities, based on clinical experience, descriptive studies and case reports, or reports of expert committees.

(Source: Harris, R.P. et al. (2001). Current methods of the U.S. Preventive Services Task Force: a review of the process. American Journal of Preventive Medicine. April 20 (3 Supplement): 21-35.)

 

Another way to look at information evidence:

The EVIDENCE PYRAMID is often used to illustrate the development of evidence. At the base of the pyramid is animal research and laboratory studies - this is where ideas are first developed. As you progress up the pyramid the amount of information available decreases in volume, but increases in relevance to the clinical setting.

Meta Analysis: systematic review that uses quantitative methods to synthesize and summarize the results.
Systematic Review:                           summary of the medical literature that uses explicit methods to perform a comprehensive literature search and critical appraisal of individual studies and that uses appropriate statistical techniques to combine these valid studies.
Randomized Controlled Trial: participants are randomly allocated into an experimental group or a control group and followed over time for the variables/outcomes of interest.
Cohort Study: involves identification of two groups (cohorts) of patients, one which received the exposure of interest, and one which did not, and following these cohorts forward for the outcome of interest.
Case Control Study: study which involves identifying patients who have the outcome of interest (cases) and patients without the same outcome (controls), and looking back to see if they had the exposure of interest.
Case Series: report on a series of patients with an outcome of interest. No control group is involved.

(Definitions from CEBM)

 

Acknowledgements

The Lister Hill Library of the Health Sciences would like to acknowledge the librarians at the Medical Center Library, Duke University, and those in the LibGuide and systematic review community for their assistance in the creation of this LHL Guide.

 

NOTA BENE

Permit me to offer a few words of advice before taking on a review.  The narrative review that is part of a term paper,  thesis or dissertation is a time-honored review method.  It will be overseen by your adviser (s) or instructor at each step so that you don’t wander off from the straight and narrow path.  Bench scientists, clinicians and graduate researchers venturing out into the world of evidence-based reviews or systematic reviews need to be aware of the tremendous amount of time and effort that is required to properly perform one of these reviews.  In particular, the research question MUST be strictly defined and clearly stated.  Otherwise, the review is doomed to fail.  I cannot over emphasize this aspect of the research process.  A vague or multifaceted research question will cause the research process to grind to a halt at the research synthesis phase and you will then have to revisit the project from the beginning.  Also, if a poorly performed review is submitted to a journal for publication, the editor will summarily reject it.  While some editors are very polite in their rejection letters, others are not and will question your scholarly and scholarship credentials.  All this is presented so that you understand what is required.  If you are willing to take on this task, the best of luck and the Reference Librarians stand ready to guide and assist you.

 

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